Enriched gene sets among high RET/GDNF tumors relative to non-high RET/GDNF tumors across (A) ESR1, (B) estrogen, and (C) antiestrogen (AE) signaling sets. (D) Heat plot of notable and significantly regulated genes across enriched estrogen, ESR1 and antiestrogen (AE) signaling sets. Enriched gene sets among high RET/GDNF tumors across (E) MYC and (F) MAPK, ERBB2, and KRAS signaling sets.