Figure 3.

Groups of heterochromatin proteins regulate distinct classes of heterochromatin and can be disrupted to facilitate gene activation. (A) Published results showing knockdowns/knockouts (blue) and overexpression (red) experiments that lead to de-repression of heterochromatin and enhanced reprogramming. (B) Regulation of H3K9me3 at genes and repeat classes by H3K9me3 HMTs, protein complexes and selected heterochromatin proteins. Green boxes indicate the indicated protein or complex has been experimentally demonstrated to regulate H3K9me3 at the designated gene or repeat class.