LaManca 1993.
Methods |
Design: randomised controlled trial Randomisation: individual Trial: daily oral iron versus placebo Date of study: not stated |
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Participants |
Setting: athletics clubs in Florida, USA Malaria endemicity: not stated Included: healthy women aged 18 years to 35 years (mean age 28 years) with ferritin < 20 ng/mL Excluded: not stated Dropouts: none reported Sample size: total: 20; intervention: 10, control: 10 |
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Interventions |
Intervention: 100 mg elemental iron daily Control: placebo Duration: 8 weeks |
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Outcomes | Iron indices, haemoglobin, hematocrit, exercise performance | |
Notes |
Compliance: iron 82% of tablets taken, placebo 85% of tablets taken Conflicts of interest: not stated Funded by: FSU President's Club fund and Sigma Xi. Tablets provided by SmithKline Laboratories |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not reported |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Placebo administered |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not reported. Assessment of exercise outcomes may be influenced by knowledge of allocation |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No loss to follow‐up |
Selective reporting (reporting bias) | Unclear risk | Not evident |
Other bias | Low risk | Not evident |