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. 2016 Apr 18;2016(4):CD009747. doi: 10.1002/14651858.CD009747.pub2

Leonard 2014.

Methods Design: randomised controlled trial
Randomisation: individual
Trial: daily oral iron (two doses) versus placebo
Date of study: 2010 to 2013
Participants Setting: women recruited via flyer through the Hunter Medical Research Institute (Australia)
Malaria endemicity: not stated
Included: women aged 18 years to 35 years (mean age 26 years) with BMI between 18 kg/m² and 30 kg/m² and English speaking
Excluded: iron deficient in last 12 months, taking iron, chronic medical condition or pregnant
Dropouts: 12 out of 36 lost to follow‐up
Sample size: total: 24; intervention: 16, control: 8
Interventions Intervention: 60 mg or 80 mg elemental iron as ferrous sulphate
Control: placebo
Duration: 16 weeks
Outcomes Haemoglobin, iron status, side effects and cognitive outcomes
Notes Compliance: on average 90.4% of capsules taken
Conflicts of interest: authors declare no conflict of interest
Funded by: Australian Post‐Graduate Award, Meat and Livestock Australia and the School of Health Sciences at the University of Newcastle
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random number generator
Allocation concealment (selection bias) Low risk Reports concealment
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Blinded
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk No evidence
Incomplete outcome data (attrition bias) 
 All outcomes High risk > 30% loss in many groups
Selective reporting (reporting bias) Low risk Not evident
Other bias Low risk Not evident