Maghsudlu 2008.
Methods |
Design: randomised controlled trial Randomisation: individual Trial: oral iron three times a day versus placebo Date of study: not stated |
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Participants |
Setting: Kermanshah and Golestan blood transfusion services, Iran Malaria endemicity: not stated Included: women attending blood donation. Age range not reported (mean age 28.7 years) Excluded: pregnancy, medical condition such as hereditary haemochromatosis chronic gastrointestinal disorder or intestinal cancer or polyps Dropouts: 207 out of 417 (50%) failed to return for follow‐up visit Sample size: total: 367, iron: 185, control: 182 |
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Interventions |
Intervention: 150 mg of ferrous sulphate three times a day Control: placebo Duration: 1 week |
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Outcomes | Haemoglobin, iron status, side effects | |
Notes |
Compliance: 75.2% of tablets taken across all groups Conflicts of interest: not stated Funded by: Iranian blood transfusion organisation |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method not stated |
Allocation concealment (selection bias) | Unclear risk | Not stated |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Unclear if double blinded |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if double blinded. Side effects reported and may be influenced |
Incomplete outcome data (attrition bias) All outcomes | High risk | 50% dropout rate |
Selective reporting (reporting bias) | Low risk | Not evident |
Other bias | Low risk | No other source of bias identified |