Fig. 3.

Effect of BMMSCs on memory and learning impairment of rats induced by Meth. (A), Morris water maze in training days showing the time latency of rats was significantly prolonged after self-administration of Meth. Mean ± SEM, **P < 0.01 versus Meth-addicted group. ## P < 0.01 versus PBS-treated groups. (B), Morris water maze probe test indicating a longer spent time in zone I (previous location of hidden platform) among BMMSC-treated rats, compared to PBS-treated rats. Mean ± SEM. *P < 0.05 versus Meth-addicted group. # P < 0.05 versus PBS-treated groups. (C), Typical trajectories in the Morris water maze probe test. Previous location of hidden platform was zone I. (Control (n=8); IV-PBS (n=4); IN-PBS (n=4); Addicted (n=7); IV-BMMSC (n=8); IN-BMMSC (n=6).