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. 2023 Apr 15;15(4):2528–2540.

Figure 7.

Figure 7

Fucoxanthin treatment inhibited glucose metabolism in ovarian cancer cells by inactivating signal transducers and activators of transcription 3 (STAT3)/c-Myc signaling. A. The 18F-fludeoxyglucose (F-FDG) uptake was detected in OVACR3 and A2780 cells after fucoxanthin and STAT3 activator treatment. B. Adenosine triphosphate (ATP) levels were measured using the ATP Assay Kit in OVCAR-3 and A2780 cells. *P<0.05, **P<0.01 and ***P<0.001. C. Extracellular acidifications rates (ECAR) of OVCAR-3 and A2780 cells was measured with a seahorse Bioanalyzer. *P<0.05 and ***P<0.001 vs Control; #P<0.05 and ##P<0.01 vs fucoxanthin. D, E. Western blot assay was performed to detect the protein expression levels of glycolysis-related rate limiting enzymes lactate dehydrogenase A (LDHA), hexokinase II (HK2), 3-Phosphoinositide-dependent protein kinase 1 (PDK1). ***P<0.001.