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The assembly of Sir proteins at HMR (chromosome III), telomeres, rDNA repeats (chromosome XII) and a DNA DSB. Sir3p is loosely associated with Sir2p and Sir4p (156). Sir proteins are recruited by Rap1p, Abf1p and ORC to HMR, whereas Sir proteins are recruited by Ku and Rap1p to telomeres. Sir2p is recruited to rDNA repeats by Net1p. The hatched box represents silencer. The filled box represents the chromosome ends. The arrow represents rDNA repeats.
