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. 2023 May 13;23:435. doi: 10.1186/s12885-023-10928-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Synthesis, characterization, and in vitro release of 4NSG: (a) Reagents and conditions for the synthesis of 4NSG (4): a) TBSCl, imidazole, DCM, rt b) DIPEA, stearic anhydride, DCM, 24 h c) TBAF DMF, rt, 2 h, (b) In vitro metabolic stability of 4NSG in PBS and human liver microsome solution (Data expressed as mean ± SD, n = 3), (c) Transmission Electron Micrograph (TEM) micrograph of 4NSG-SLN (Scale bar = 500 nm), (d) Cumulative 4NSG release from free 4NSG, freshly prepared 4NSG-SLN, and lyophilized 4NSG-SLN in PBS (phosphate-buffered saline; pH 7.4 at 37 °C)