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. 2023 May 13;23:435. doi: 10.1186/s12885-023-10928-w

Table 6.

Pharmacokinetic profiles after GemHCl and 4NSGSLN were administered intravenously to mice

Parameter Unit Comparison p-value
GemHCl 4NSG-SLN
k10 1/h 1.01 ± 0.03 0.36 ± 0.04 0.0001
t1/2 H 0.70 ± 0.01 1.93 ± 0.06 0.0001
Vd mL 21.7 ± 1.9 19.3 ± 0.2 0.3619
Cl mL/h 21.3 ± 3.2 7.1 ± 1.1 0.0001
AUC(0-t) µg/(mL*h) 28.2 ± 4.3 86.2 ± 5.4 0.0001

K10, elimination rate constant; t1/2, half-life; AUC(0-t), area under the plasma concentration–time curve; Cl Clearance, Vd Volume of distribution; (Data analyzed using t-test)