Fig. 1.

Radiosensitivity of H460, Calu-1 and A549 cells. A Clonogenic assays showing varying radioresistance at 21% O₂ (upper plot) and 0.1% O₂ (lower plot). Cell lines were irradiated with doses ranging from 2 to 8 Gy in normoxia and 4–16 Gy in hypoxia. B The respective survival curves separated for each cell line. Each data point is presented as mean ± SD of three separate experiments performed in quintuplicate. The survival fractions were normalized to the respective 0 Gy samples. ***p < 0.001 as compared to 0 Gy normoxia; ⁺⁺⁺p < 0.001 as compared to 0 Gy hypoxia