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. 2023 May 13;16(8):1149–1157. doi: 10.1016/j.jiph.2023.05.013

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© 2023 The Authors

Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.

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Fig. 2 — Timeline for monkeypox infection clarifying the pathogenesis through the first 12 days of infection. The initial replication occurs around the second day at the primary site of inoculation. After day seven of infection, the initial symptoms (secondary viremia) of monkeypox happened and seeding to additional tissues, this includes a 2- to 3-day febrile illness, usually occurring from 10 to 14 days after initial exposure. Also, the characteristic skin lesions developed.