Table 2.

Clinical performance characteristics

Detection of Any Cancer at Biopsy
Parameter	Value	95% CI
Sensitivity	74.1%	63.1%−83.1%
Specificity	60.0%	51.1%−68.5%
Disease prevalence	38.4%	N/A
PPV	53.6%	47.4%−59.6%
NPV	78.8%	71.5%−84.6%
Detection of High-grade Cancer at Biopsy
Sensitivity	77.8%	57.7%−91.4%
Specificity	52.7%	45.2%−60.1%
Disease prevalence	12.8%	N/A
PPV	19.4%	15.8%−23.7%
NPV	94.2%	88.7%−97.1%

CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.