Table 2.

Risk factors of pancreas-only recurrence

Variable	Univariate analysis		Multivariable analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Gender (F/M)	1.06 (0.54–2.05)	0.871
Age (<65/≥65)	1.17 (0.56–2.45)	0.673
Functional status	1.20 (0.16–8.82)	0.859
Genetic syndrome	3.59 (1.76–7.32)	0.000	4.41 (1.34–14.52)	0.015
Symptomatic	1.25 (0.63–2.46)	0.524
Ki-67 category
<3%	Ref.		Ref.
3–20%	1.41 (0.54–3.65)	0.484	2.12 (0.68–6.61)	0.197
>20%	4.95 (1.06–23.01)	0.042	1.00	0.992
Tumor differentiation
Well	Ref.		Ref.
Moderately	0.90 (0.21–3.85)	0.886	0.32 (0.04–2.77)	0.302
Poorly	6.25 (1.45–26.90)	0.014	1.18	1.000
Largest tumor size (<3 cm/≥3 cm)	2.36 (1.22–4.60)	0.011	1.15 (0.33–3.99)	0.825
Lymph nodes metastasis	1.61 (0.76–3.41)	0.215
Perineural invasion	0.24 (0.03–1.79)	0.163
Lymph-vascular invasion	2.34 (1.08–5.08)	0.031	1.16 (0.33–4.13)	0.818
Surgical technique		0.268
Open	Ref.
Laparoscopic/robotic	0.55 (0.19–1.58)
Major vascular resection	3.14 (1.10–9.01)	0.033	1.12 (0.13–9.45)	0.919
Final resection status		0.002		0.003
R0	Ref.		Ref.
R1	3.16 (1.55–6.46)		5.12 (1.74–15.40)
Adjuvant chemotherapy	6.23 (1.87–20.72)	0.003	2.16 (0.24–19.53)	0.495