Table 3.

Risk factors of liver-only recurrence

Variable	Univariate analysis		Multivariable analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Gender (F/M)	0.96 (0.61–1.50)	0.842
Age (<65/≥65)	0.77 (0.44–1.34)	0.351
Functional status	0.05 (0.00–23.24)	0.335
Genetic syndrome	0.52 (0.21–1.28)	0.153
Symptomatic	2.24 (1.37–3.66)	0.001	2.08 (0.77–5.63)	0.149
Ki-67 category
<3%	Ref.		Ref.
3–20%	6.24 (2.89–13.58)	0.000	2.85 (1.05–7.73)	0.040
>20%	19.15 (6.92–53.02)	0.000	6.98 (1.21–40.35)	0.030
Tumor differentiation
Well	Ref.		Ref.
Moderately	2.83 (1.55–5.18)	0.001	2.34 (0.45–12.28)	0.314
Poorly	5.51 (1.98–15.39)	0.001	0.43 (0.05–3.73)	0.443
Largest tumor size (<3 cm/≥3 cm)	6.72 (3.92–11.53)	0.000	1.79 (0.67–4.76)	0.245
Lymph nodes metastasis	3.40 (2.14–5.38)	0.000	2.01 (0.88–4.60)	0.098
Perineural invasion	5.83 (3.37–10.10)	0.000	3.66 (1.53–8.72)	0.003
Lymphvascular invasion	6.32 (3.53–11.30)	0.000	0.50 (0.18–1.36)	0.174
Surgical technique		0.002		0.287
Open	Ref.		Ref.
Laparoscopic/robotic	0.21 (0.08–0.56)		0.45 (0.10–1.98)
Major vascular resection	5.01 (2.80–9.00)	0.000	3.23 (1.13–9.23)	0.029
Final resection status		0.541
R0	Ref.
R1	1.21 (0.66–2.30)
Adjuvant chemotherapy	6.49 (3.10–13.57)	0.000	4.62 (1.41–15.08)	0.011