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. 2023 May 13;6:517. doi: 10.1038/s42003-023-04907-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Table of proteins participating in haem (left) or iron (right) homoeostasis, together with their expression values (FPKM) of their mRNA transcripts across libraries derived from individual developmental stages of Dermanyssus gallinae. Accession numbers are available in Supplementary Table S6. UP unfed protonymphs, FP fed protonymphs, FD fed deutonymphs. alas, 5-aminolevulinate synthase; pbgs, porphobilinogen synthase; hmbs, hydroxymethylbilane synthase; uros, uroporphyrinogen synthase; urod, uroporphyrinogen decarboxylase; cpox, coproporphyrinogen oxidase; ppox, protoporphyrinogen oxidase; fech, ferrochelatase; ho, haem oxygenase; fer, ferritin; tf, transferrin; irp, iron-responsive protein. b The LC/MS analysis of Haem b precursors in the naive non-fed stages of D. gallinae. Reconstructed chromatograms for the D. gallinae samples are shown on top, with reconstructed chromatograms for their analytical standards below. c A schematic of haem biosynthesis, which identifies (filled circles) transcripts and metabolites of the pathway. ALA δ-aminolevulinic acid, PBG porphobilinogen, HMB hydroxymethylbilane, URO uroporphyrinogen, CPP coproporphyrinogen, PP protoporphyrin. d A photographic image of eggs of D. gallinae mites and Ixodes ricinus ticks; note the colour difference, indicating the absence/presence of maternal haem deposits.