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. 2023 May 13;6:516. doi: 10.1038/s42003-023-04905-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The C57BL/6 mice pups were exposed to 75% oxygen from P7 to P12 and then returned to room air. At P15, eyes from normoxia and 3 days post OIR/hypoxia were enucleated, retinas isolated, and total cellular RNAs were extracted and subjected to mRNA sequencing. a Volcano plot shows the number of genes (represented as yellow dots) that are significantly upregulated or downregulated in the hypoxic retina compared to normoxia. b Heatmap showing the expression profile of CXCL and its related genes in normoxia and hypoxia. c The genes that were significantly upregulated or downregulated in hypoxia compared to normoxia are presented as fold change. d At various periods of relative hypoxia, eyes were enucleated from C57BL/6 mice, retinas were isolated, and total RNA was extracted and analyzed for CXCL1 and GAPDH mRNA levels by QRT-PCR. n = 6 (d) biologically independent samples per group, expressed as Mean ± SD. *P < 0.05 vs normoxia.