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. Author manuscript; available in PMC: 2023 May 14.
Published in final edited form as: Breast Cancer Res Treat. 2016 Oct 22;160(3):457–474. doi: 10.1007/s10549-016-4011-9

Fig. 1.

Fig. 1

Spectrum of hotspot mutations in PIK3CA across subtypes of breast cancer. a Spectrum of hotspot mutations of PIK3CA in breast cancer based on The Cancer Genome Atlas (TCGA) data (December 2015). b and c Overlap of mutations in PIK3CAH1047R or PIK3CAWT patients with two other subtypes of breast cancer: anti-epidermal growth factor receptor 2 positive (HER2+) or negative (HER2−) (b) and estrogen receptor positive (ER+) or negative (ER−) (c). d and e, Kaplan–Meier overall survival rates for breast cancer patients with or without two PIK3CA hotspot mutations (H1047R and E545K) using TCGA data [7, 8]. All P values of Kaplan–Meier survival analysis were performed using a log-rank test