Table 3.

l-Carnitine dosing.

Patient	Carnitine dosing	Carnitine timing
1	50mg/kg/d IV divided q8h then 100mg/kg/d IV divided q8h	Lower dose on Induction Day 23; higher dose on Induction Days 24–41 (19 d)
2	100mg/kg/d PO divided q8h	Induction Day 27 through Consolidation Day 29 (38 d) and Consolidation Days 40–56 (17 d)
3	45mg/kg/d IV divided q8h then PO at same dose	IV on Induction Day 33 through Consolidation Day 2 (19 d); PO from Consolidation Day 3 through end of Delayed Intensification (approximately 6 months)
4	50mg/kg/d IV divided q12h then PO at same dose	IV on Induction Days 22–26 (5 d); PO on Induction Day 27 through Consolidation Day 13 (22 d)
5	990 mg PO BID (18mg/kg/d)	First course given as prophylaxis on Induction Days 1–29 (30 d); future courses started the day of PEG-asparaginase administration and continued for 14 d each
6	85 mg/kg/d IV divided q8h then PO at same dose	IV on Induction Days 25–29 (5 d); PO on Induction Day 30 through Consolidation Day 22 (28 d); future courses given for 1 week before and 1 week after each dose of PEG-asparaginase

IV: intravenously; PO: orally; BID: twice daily.