Table 5. Favorable tumor immune microenvironment according to the literature.

Component	Description
PD-L1 expression	High PD-L1 expression favorable for immunotherapy
TIL	High TIL density favorable for immunotherapy
CD 8 cell	Density of CD103+ CD8+ cells in tumor tissues showed significant association with improved progression-free survival in patients receiving immunotherapy
T effector cell	T effector cells play a central role in cytotoxic cell death; however, Treg cells are associated with immune evasion of tumor cells
T reg	Teff/Treg cell ratio showed potential prognostic and predictive values in many tumor types
Plasma cell	Plasma cell signatures were also reported to have predictive value for improved overall survival in non-small cell lung cancer patients receiving immunotherapy

PD-L1, programmed death-ligand 1; TIL, tumor-infiltrating lymphocytes.