Table 5:

Efficacy of produced antiparasitic drugs in combating equine strongylosis

Experiment number / group of animals	Test product	Dose (mg of active substance /kg BW)	Number of horses in group	% infected	EPGa mean	EEb %	IEc %	Efd %	P valuee
1 / Control	Placebo	–	10	100	252.5±40.7f 2.36±0.1	–	–	–	–
1 / Treatment	PPIA-1g	0.2 IVMh 10.0 ALBi	10	0.0	0 0	100.0	100.0	100.0	NAj
2 / Control	Placebo	–	20	75.0	167.2±28.1 2.31±0.08	–	–	–	–
2 / Treatment	PPIANk	0.2 IVM 10.0 ALB 10.0 NSl	16	0.0	0 0	100.0	100.0	100.0	NA
3 / Control	Placebo	–	12	100	565.2±54.3 2.71±0.05	–	–	–	–
3 / Treatment	PPIA-2-1m	0.2 IVM 10.0 ALB	14	21.4	9.1±5.1 1.6±0.1	78.6	98.4	41.0	< 0.01
3 / Treatment	PPIA-2-3n	0.2 IVM 3.0 ALB	13	0.0	0 0	100.0	100.0	100.0	NA
3 / Treatment	PPIA-2-5o	0.2 IVM 5.0 ALB	11	0.0	0 0	100.0	100.0	100.0	NA
3 / Treatment	PPI-initialp	0.2 IVM	12	50.0	66.9±20.1 1.99±0.1	50.0	88.2	26.6	< 0.01
3 / Treatment	PPA-initialq	10.0 ALB	10	40.0	57.8±19.8 2.1±0.05	60.0	89.8	22.5	< 0.01
4 / Control	Placebo	–	16	100	464.3±95.6 2.51±0.08	–	–	–	–
4 / Treatment	Ivermec®	0.2 IVM	7	85.7	16.6±3.4 1.26±0.06	14.3	96.5	49.8	< 0.01

^aEPG: egg per gram of faeces;

^bEE: the proportion of animals freed from parasites in relation to the untreated control animals;

^cIE: decrease in the arithmetic mean number of eggs of the experimental groups in relation to the control;

^dEf: decrease in the geometric mean number of eggs of the experimental groups in relation to the control;

^estatistically significant at P ≤ 0.05 when geometric means were compared to placebo;

^fThe numerator is the arithmetic mean and the denominator is the geometric mean number of eggs;

^g1 mL of PPIA-1 paste contained 10 mg of ivermectin and 500 mg of albendazole;

^hIVM: ivermectin;

ⁱALB: albendazole;

^jNA: statistical analysis was not performed;

^k1 mL of PPIAN paste contained 10 mg of IVM, 500 mg of ALB and 500 mg of niclosamide;

^lNS: niclosamide;

^m1 mL of PPIA-2-1 paste contained 10 mg of IVM and 50 mg of ALB;

ⁿ1 mL of PPIA-2-3 paste contained 6.7 mg of IVM and 100 mg of ALB;

^o1 mL of PPIA-2-5 paste contained 5 mg of IVM and 125 mg of ALB;

^p1 mL of PPI-initial paste contained 10 mg of IVM;

^q1 mL of PPA-initial paste contained 500 mg of ALB