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. 2023 May 1;14:1192940. doi: 10.3389/fimmu.2023.1192940

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Copyright © 2023 Sun, Li, A, Li, Zhong, Chen, Liu, Zhang, Zhu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MP can alleviate cognitive dysfunction in Aβ_1-42-induced mice. Once injected with Aβ_1-42 (10 ug, 5 uL, i.c.v.), the mice were treated with MP (25 mg/kg, i.g.). (A) Schematic of experimental design. (B) The spontaneous alternation performance in the Y-maze test. (C) Path length of each group. (D) Average swimming speed of each group. (E) Spent time in the target quadrant at the last exploration trial. (F) The latency to find the target platform during training trials and the last exploration trail. (G) The swimming paths of mice finding the hidden platform at the last exploration trial. Data are shown as mean ± SEM (n=10). *P < 0.05 vs. control group; ^#P < 0.05 vs. Aβ_1-42-induced group.