Table 1.
Baseline Characteristics of Control Subjects and Patients with POAG
| Control (n = 38) | POAG (n = 32) | P value | |
|---|---|---|---|
| Systemic characteristics | |||
| Age (yrs) | 70.3 ± 8.4 | 68.8 ± 11.1 | 0.64 |
| Gender (% male) | 39.5 | 62.5 | 0.055 |
| Race (% White) | 97.4 | 78.1 | 0.01 |
| Body mass index (kg/m2) | 25.8 ± 4.3 | 25.7 ± 3.8 | 0.89 |
| Systemic hypertension (%) | 51.4 | 37.5 | 0.29 |
| Ophthalmic characteristics | |||
| Visual acuity (Snellen, logMAR) | 20/23, 0.06 ± 0.08 |
20/22, 0.04 ± 0.07 |
0.18 |
| Spherical equivalent (diopters)∗ | -0.01 ± 1.8 | 0.1 ± 2.3 | 0.85 |
| Prior cataract surgery in ≥ 1 eye (%) | 60.0 | 46.9 | 0.48 |
| Prior penetrating glaucoma surgery in ≥ 1 eye (%) | - | 18.7 | - |
| Prior minimally invasive glaucoma surgery in ≥ 1 eye (%) | - | 28.1 | - |
| Intraocular pressure-lowering medications | - | 2.0 ± 1.3 | - |
| Intraocular pressure (mmHg)† | 15.3 ± 2.2 | 13.3 ± 2.8 | 0.003 |
| Cup-to-disc ratio | 0.3 ± 0.1 | 0.7 ± 0.1 | < 0.001 |
| Retinal nerve fiber layer thickness (μm) | 99.8 ± 10.0 | 76.2 ± 13.3 | < 0.001 |
| HVF MD (dB) | - | -4.7 ± 4.0 | - |
| OCTA measurements‡ | |||
| cpVD (%) | 43.0 ± 2.7 | 40.0 ± 2.9 | < 0.001 |
All data are presented as mean ± standard deviation unless specified otherwise. Significant P values are in bold.
cpVD = circumpapillary vessel density; HVF = Humphrey visual field; logMAR = logarithm of the minimum angle of resolution; MD = mean deviation; OCTA = OCT angiography; POAG = primary open-angle glaucoma.
∗
Only calculated for patients who had both eyes phakic as an average of spherical equivalent of both eyes.
†
Intraocular pressure was measured on the day of blood draw. All patients with POAG received treatment for intraocular pressure.
‡
Available for 78.9% controls (n = 30) and 87.5% patients with POAG (n = 28).