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. 2023 May 15;270(7):3315–3328. doi: 10.1007/s00415-023-11768-1

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 4 — Summary receiver operating characteristic curve (SROC) for the diagnostic accuracy of NfL Z score for predicting death. Specificity 75%: optimal cut-off 2.73 (sensitivity 0.49, specificity 0.79), specificity 85%: optimal cut-off 3.06 (sensitivity 0.36, specificity 0.86), specificity 95%: optimal cut-off 4.01 (sensitivity 0.09, specificity 0.96). At maximized Youden-Index (green diamond): optimal cut-off 1.96 (sensitivity 0.78, specificity 0.59)