Table 2.
Associations between NfL Z scores and other demographical, laboratory and clinical variables (univariate GLMM, centre as random effect).
| Univariate GLMM analysis | Estimate (95%CI) | P value | n. cases |
|---|---|---|---|
| Male Sex | 0.174 (− 0.040 – 0.389) | 0.112 | 649 |
| Current disease | |||
| Time from onset to admission | − 0.006 (− 0.034 – 0.022) | 0.685 | 241 |
| Time from onset to blood sampling (disease duration) | 0.040 (0.024–0.056) | < 0.0001 | 399 |
| COVID-19 severity (severe vs. moderate) | 0.715 (− 0.614–2.044) | 0.379 | 431 |
| COVID-19 severity (critical vs. moderate) | 1.364 (0.686–2.042) | 0.0001 | |
| Medical history | |||
| Diabetes mellitus | 0.728 (0.380–1.077) | 0.0001 | 377 |
| Hypertension | 0.347 (0.072–0.623) | 0.014 | 394 |
| Laboratory parameters | |||
| Absolute lymphocyte count | 0.031 (− 0.043–0.104) | 0.462 | 249 |
| Absolute neutrophil count | 0.005 (− 0.022–0.031) | 0.736 | 152 |
| CRP | 0.002 (0.0006–0.004) | 0.005 | 302 |
| LDH | 0.001 (0.0003–0.002) | 0.003 | 211 |
| Creatinine | 0.948 (0.613–1.283) | < 0.0001 | 149 |
| PaO2/FiO2 ratio | − 0.003 (− 0.004– − 0.001) | 0.0003 | 141 |