4. Summary of outcomes by trials ‐ primary prevention.

Outcome	Death	Death (CV causes)	Non‐fatal MI	Stroke	Angina	Venous thromboembolism	Pulmonary embolism	Revascularisation
Trial
DOPS 2012	✓	✓	✓	✓	X	✓	X	X
EPAT 2001	X	X	✓	X	X	X	X	✓
EPHT 2006	✓	X	X1	X	X	X	X	X
ERT II 1979	✓	X	✓	X	X	X	X	X
Greenspan 2005	✓	X	✓	X	X	✓	X	X
STOP IT 2001	✓	X	✓	✓	X	✓	X	X
WHI I 2002	✓	✓	✓	✓	✓	✓	✓	✓
WHI II 2004	✓	✓	✓	✓	✓	✓	✓	✓
WISDOM 2007	✓	X	X	X	X	✓	✓	X
Number of trials	8	3	7	4	2	6	3	3
Total N	34,422	28,353	29,482	28,719	27,347	33,477	31,732	27,569

¹ No events in control group.
 CV: cardiovascular; MI: myocardial infarction