6. Trials according to number of years since menopause when treatment commenced.

Study	Population	Time since menopause (years)	Mean age (years)
< 10 years since menopause (or mean age < 60)
DOPS 2012	1006	0.59
ERT II 1979	168	4.6
EPHT 2006	1178	8.8
EVTET 2000	140	NK3	55.7
WHI I 2002	5494	< 10 yrs
WHI II 2004	1643	< 10 yrs
TOTAL	9629
≥ 10 years since menopause (or mean age ≥ 60)
WHI I 2002	9694	≥ 10
WHI II 2004	7468	≥ 10
HALL 1998	373	12.5
WISDOM 2007	4385	14.7
ESPRIT 2002	1017	16.1
HERS I 1998	2763	18
WELL‐HART 2003	226	18.2
WHISP 2006	100	22.8
ERA 2000	309	23.0
WEST 2001	664	25
EPAT 2001	222	NK3	62.2
EAGAR 2006	83	NK1	64
WAVE 2002	423	NK2	65
STOP IT 2001	489	NK1	71
Greenspan 2005	489	NK3	71.2
TOTAL	28705
1Author contacted but data was not collected. 2Author contacted; reported data available from National Institutes of Health (NIH) (who funded trial) but data currently pending. 3Author emailed, but no reply. NK: not known