Skip to main content
. 2023 Mar 31;29(10):1894–1905. doi: 10.1158/1078-0432.CCR-22-3136

Figure 4.

Figure 4. Mixed model with repeated measures for change from baseline for prespecified patient-reported outcome endpoints in patients ≥65 years. Results were populated through month 15 due to lack of model convergence when using time points. Figures are based on Model 1. Horizontal lines, provided for clarity of interpretation, indicate the minimally important difference thresholds for clinically meaningful change. Mixed model includes variables for treatment, time, and treatment by time interaction (primary analysis) and is controlled for response to first-line therapy and age-adjusted IPI at screening. a P < 0.05. A, The change from baseline of EORTC QLQ-C30 Physical Functioning in patients ≥65 years. B, The change from baseline of EORTC QLQ-C30 Global Health Status in patients ≥65 years. C, The change from baseline of EQ-5D-5 L VAS in patients ≥65 years.

Mixed model with repeated measures for change from baseline for prespecified patient-reported outcome endpoints in patients ≥65 years. Results were populated through month 15 due to lack of model convergence when using time points. Figures are based on Model 1. Horizontal lines, provided for clarity of interpretation, indicate the minimally important difference thresholds for clinically meaningful change. Mixed model includes variables for treatment, time, and treatment by time interaction (primary analysis) and is controlled for response to first-line therapy and age-adjusted IPI at screening. *, P < 0.05. A, The change from baseline of EORTC QLQ-C30 Physical Functioning in patients ≥65 years. B, The change from baseline of EORTC QLQ-C30 Global Health Status in patients ≥65 years. C, The change from baseline of EQ-5D-5L VAS in patients ≥65 years.