Table 1. Reports of potential vertical transmission.
Case | Country; city; hospital | Age (years) | Gestational age | Birth weight | Apgar score | Delivery | Main findings | Interval between onset of maternal disease and diagnosis in the neonate | Reasons why vertical transmission is not justified (or justified) |
---|---|---|---|---|---|---|---|---|---|
#1 Wang et al., 7 Hu et al., 8 Yu et al. 9 |
China; Wuhan; Tongji Hospital | 34 | 39 weeks 6 days | 3,250 g | 8/9 | Cesarean | Positive RT-PCR in th oropharynx swab – newborn 36 hours after delivery. | 8 hours of maternal symptoms + 36 hours postpartum | Not justified: RT-PCR the in oropharynx swab collected after more than 12 hours of delivery. |
#2 Dong et al. 10 |
China; Wuhan; Renmin Hospitalof Wuhan University | 29 | 37weeks 6 days | 3,120 g | 9/10 | Cesarean | Positive IgM and IgG 2 hours after delivery; negative RT-PCR in the oropharynx swab; IgM and IgG levels were reduced after 2 weeks; discharged. |
25 days | Not justified: discordance among exams and negative RT-PCR in the oropharynx swab. |
#3 Zamaniyan et al. 11 |
Iran; Sari; Imam Khomeini Hospital | 22 | 32 weeks | 2,350 g | 8/9 | Cesarean | Positive RT-PCR in the amniotic fluid collected during cesarean section (contamination?); negative RT-PCR in the oropharynx swab of the newborn; maternal death postpartum. | 7 days | Not justified: positive RT-PCR in the amniotic fluid, but with the possibility of contamination with no other confirmation of the virus. |
#4 Li et al. 5 and Ferrazzi et al. 12 |
China; Wuhan; Hubei Provincial Maternal and Child Health Center; 5 and Italy; Lombardy and Units of Padua and Modena 12 | NR | NR | NR | NR | Vaginal | Positive RT-PCR in two newborns. In these two cases, because viral testing was not performed immediately after birth, postpartum transmission cannot be excluded. | Not informed | Not justified: the swab test was not performed shortly after birth. |
#6 Alzamora et al. 13 |
Peru; Lima; British American Hospital | 41 | 33 weeks | 2,970 g | 6/8 | Cesarean | Positive RT-PCR in the nasopharyngeal swab – newborn 16 hours after delivery. Repeated in 48 hours: also positive. | 5 days | Not justified: RT-PCR in the nasopharyngeal swab collected 12 hours after delivery. |
#7 Vivanti et al. 14 |
France; Paris Saclay University Hospitals | 23 | 35 weeks 5 days | 2,540 g | 4/1 | Cesarean | Amniotic fluid collected during cesarean section positive on RT-PCR (Genes E and S). Nasopharyngeal and rectal swabs collected within 1 hour, 3 days and 18 days of life were positive on RT-PCR (Genes E and S). Blood and non-bronchoscopic bronchoalveolar lavage fluid collected before extubation (6 hours after delivery) positive on RT-PCR (Genes E and S). |
5 days | Justified: positive RT-PCR in the amniotic fluid and in the neonate blood sample collected before 12 hours of delivery. |
#8 Mehta et al. 15 |
United States; Liningston; Saint Barnabas Medical Center | 39 | 27 weeks | Baby A: 925 g; Baby B: 1,050 g |
Baby A: 1/3; Baby B: 5/6 |
Cesarean | Twin A tested positive and twin B tested negative for SARS-CoV-2 at 72 hours, and it is not clear what type of test was performed. The authors believe that twin A tested positive due to vertical transmission. | 14 days | Not justified: the type of test performed is not described properly, and it was performed 12 hours after delivery. |
#9 Sun et al. 16 |
China; Henan; Henan Provincial People's Hospital | 28 | 37 weeks | Not informed | 9/9 | Cesarean | Obstetricians, anesthesiologists, neonatologists, and nurses wore full personal protective equipment, including an N95 mask, eye goggles, face shield, and a top-to-bottom tight-fitting gown, entering the operating theaters ∼ 5 minutes before the patients. Neonate tested positive for SARS-CoV-2 at day 6 postpartum. | 9 days of maternal symptoms + 6 postnatal days | Not justified: RT-PCR in the oropharynx swab collected 12 hours after delivery. |
Abbreviations: IgG, immunoglobulin G; IgM, immuniglobulin M; NR, not reported; RT-PCR, real-time polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.