Skip to main content
. 2021 Apr 15;43(3):207–215. doi: 10.1055/s-0040-1722256

Table 1. Reports of potential vertical transmission.

Case Country; city; hospital Age (years) Gestational age Birth weight Apgar score Delivery Main findings Interval between onset of maternal disease and diagnosis in the neonate Reasons why vertical transmission is not justified (or justified)
#1
Wang et al., 7 Hu et al., 8 Yu et al. 9
China; Wuhan; Tongji Hospital 34 39 weeks 6 days 3,250 g 8/9 Cesarean Positive RT-PCR in th oropharynx swab – newborn 36 hours after delivery. 8 hours of maternal symptoms + 36 hours postpartum Not justified: RT-PCR the in oropharynx swab collected after more than 12 hours of delivery.
#2
Dong et al. 10
China; Wuhan; Renmin Hospitalof Wuhan University 29 37weeks 6 days 3,120 g 9/10 Cesarean Positive IgM and IgG 2 hours after delivery;
negative RT-PCR in the oropharynx swab;
IgM and IgG levels were reduced after 2 weeks;
discharged.
25 days Not justified: discordance among exams and negative RT-PCR in the oropharynx swab.
#3
Zamaniyan et al. 11
Iran; Sari; Imam Khomeini Hospital 22 32 weeks 2,350 g 8/9 Cesarean Positive RT-PCR in the amniotic fluid collected during cesarean section (contamination?); negative RT-PCR in the oropharynx swab of the newborn; maternal death postpartum. 7 days Not justified: positive RT-PCR in the amniotic fluid, but with the possibility of contamination with no other confirmation of the virus.
#4
Li et al. 5 and Ferrazzi et al. 12
China; Wuhan; Hubei Provincial Maternal and Child Health Center; 5 and Italy; Lombardy and Units of Padua and Modena 12 NR NR NR NR Vaginal Positive RT-PCR in two newborns. In these two cases, because viral testing was not performed immediately after birth, postpartum transmission cannot be excluded. Not informed Not justified: the swab test was not performed shortly after birth.
#6
Alzamora et al. 13
Peru; Lima; British American Hospital 41 33 weeks 2,970 g 6/8 Cesarean Positive RT-PCR in the nasopharyngeal swab – newborn 16 hours after delivery. Repeated in 48 hours: also positive. 5 days Not justified: RT-PCR in the nasopharyngeal swab collected 12 hours after delivery.
#7
Vivanti et al. 14
France; Paris Saclay University Hospitals 23 35 weeks 5 days 2,540 g 4/1 Cesarean Amniotic fluid collected during cesarean section positive on RT-PCR (Genes E and S).
Nasopharyngeal and rectal swabs collected within 1 hour, 3 days and 18 days of life were positive on RT-PCR (Genes E and S).
Blood and non-bronchoscopic bronchoalveolar lavage fluid collected before extubation (6 hours after delivery) positive on RT-PCR (Genes E and S).
5 days Justified: positive RT-PCR in the amniotic fluid and in the neonate blood sample collected before 12 hours of delivery.
#8
Mehta et al. 15
United States; Liningston; Saint Barnabas Medical Center 39 27 weeks Baby A: 925 g;
Baby B: 1,050 g
Baby A: 1/3;
Baby B: 5/6
Cesarean Twin A tested positive and twin B tested negative for SARS-CoV-2 at 72 hours, and it is not clear what type of test was performed. The authors believe that twin A tested positive due to vertical transmission. 14 days Not justified: the type of test performed is not described properly, and it was performed 12 hours after delivery.
#9
Sun et al. 16
China; Henan; Henan Provincial People's Hospital 28 37 weeks Not informed 9/9 Cesarean Obstetricians, anesthesiologists, neonatologists, and nurses wore full personal protective equipment, including an N95 mask, eye goggles, face shield, and a top-to-bottom tight-fitting gown, entering the operating theaters ∼ 5 minutes before the patients. Neonate tested positive for SARS-CoV-2 at day 6 postpartum. 9 days of maternal symptoms + 6 postnatal days Not justified: RT-PCR in the oropharynx swab collected 12 hours after delivery.

Abbreviations: IgG, immunoglobulin G; IgM, immuniglobulin M; NR, not reported; RT-PCR, real-time polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.