Figure 6.

Inhibition of GC with ODQ (10 μmol/L) converts a negative contractile response of SNAP (10 μmol/L) to a sustained positive response. The bar graph depicts the average change in contraction amplitude, expressed as a fraction of the basal contraction, after 20 minutes of exposure of cells to SNAP (10 μmol/L) either in the absence or presence of ODQ (10 μmol/L). SNAP alone significantly attenuated contraction amplitude by 26±4%, whereas in the presence of ODQ, SNAP induced a pronounced increase in contraction, 28±10% above baseline. *P<0.05 vs basal level.