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. Author manuscript; available in PMC: 2023 May 15.
Published in final edited form as: Circ Res. 1999 May 14;84(9):1020–1031. doi: 10.1161/01.res.84.9.1020

Figure 7.

Figure 7.

Tonic PDE inhibition with IBMX does not prevent the positive contractile response of SNAP. Top, Typical continuous chart recording of contraction amplitude in response to IBMX (0.1 mmol/L) followed by SNAP (1 μmol/L) in the continued presence of IBMX. Bottom, Representative example of the effect of IBMX and SNAP (same protocol as in the top panel) on contraction and [Ca2+]i from a different myocyte. Each tracing is taken at steady state under the condition listed. Note that even in the presence of IBMX, SNAP can still exert a positive inotropic effect via an increase of the Cai.