Table 1.
Detailed eligibility criteria for the SWET‐RA trial
| Inclusion criteria |
|---|
| Age 60‐80 y |
| Internet access |
| Body mass index 28‐40 kg/m2 |
| Seropositive (positive rheumatoid factor or anticitrullinated protein antibody) or erosions typical of rheumatoid arthritis on radiographs |
| Exclusion criteria |
| Subject unwilling/unable to use online platforms (eg, ZOOM, REDCap, Pattern Health) for study activities |
| Current use of biologic agents other than those targeting tumor necrosis factor α |
| Current (within the last month) pharmacologic therapy with corticosteroids at doses greater than prednisone 5 mg/d (or equivalent glucocorticoid doses) |
| Other inflammatory arthropathy or myopathy, Paget disease, pigmented villonodular synovitis, joint infection, ochronosis, neuropathic arthropathy, osteochondromatosis, acromegaly, hemochromatosis, or Wilson disease |
| Participating in regular exercise within the past 3 mo (according to 2018 Physical Activity Guidelines for Americans: not more than 150 min/wk of moderate‐intensity exercise or 75 min/wk of vigorous‐intensity exercise) |
| New medications within the last 3 mo |
| Medication‐dose fluctuation within the last 30 d |
| Occurrence of coronary events consisting of occlusive disease (per cardiac catheterization or ST‐elevation myocardial infarction), acute heart failure, or documented dysrhythmia within the last 12 mo |
| Current presence of aortic stenosis rated moderate or worse |
| Diagnosis of type 2 diabetes mellitus |
| Absolute contraindications to exercise: Recent (<6 mo) acute cardiac event, unstable angina, uncontrolled dysrhythmias causing symptoms or hemodynamic compromise, symptomatic aortic stenosis, uncontrolled symptomatic heart failure, acute pulmonary embolus, acute myocarditis or pericarditis, suspected or known dissecting aneurism, or acute systemic infection |
| Relative contraindications to exercise: Left main coronary stenosis, moderate stenotic valvular heart disease, outflow tract obstruction, high degree AV block, ventricular aneurysm, uncontrolled metabolic disease (eg, diabetes, thyrotoxicosis, myxedema), uncontrolled pulmonary disease (eg, severe COPD or pulmonary fibrosis), and mental (including severe depression or anxiety) or physical impairment leading to inability to exercise adequately |
| Significant weight change (gain or loss of >10 lb in 1 mo) within the past 6 mo |
| Unwillingness or inability to adhere to the diet structure of the study |
Abbreviations: AV, Atrioventricular; COPD, chronic obstructive pulmonary disease; ST, segment; SWET‐RA, Supervised Weight Loss Plus Exercise Training‐rheumatoid arthritis.