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Reagents and conditions: (a) NaH, Tf2O, 0 °C to rt, 1 h, 70%; (b) HCOONa, DMF, LiCl, Ac2O, DIPA, XPhos-Pd-G2, 0 °C then 50 °C, 18 h, 57%; (c) EDC·HCl, CHCl3, rt, 2 h, then 33d, NEt3, reflux, 18 h, 13%; (d) LiOH, THF/H2O, rt, 20 min, 95%; (e) XPhos-Pd-G2, Cs2CO3, PhCH3/EtOH/DMF/H2O, 100 °C, 18 h, 59–99%.
