Scheme 7. Synthesis of N-Methylamine Building Block 9a.
Reagents and conditions: (a) (Boc)2O, N,N-diisopropylethylamine, dimethylformamide (DMF), rt, 2 h, 77%; (b) NaH, THF, 0 °C, 1 h; then CH3I, rt, 4 h, 72%; (c) HCl, 1,4-dioxane, rt, 1 h.
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