Table 5.
Allele and genotype frequencies of genetic polymorphisms among cases and controls and their main effects on stroke risks in both sexes.
| Sex | SNP | Cases | % | Controls | % | OR (95% CI)*a | p valueb | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Male | rs17276588 genotype | |||||||||
| GG (ref) | 532 | 51.6 | 696 | 84.3 | 1.00 (ref) | |||||
| AA | 500 | 48.4 | 130 | 15.7 | 4.403 (3.475–5.578) | <0.001 | ||||
| rs17276588 allele | ||||||||||
| G (ref) | 1064 | 51.6 | 1392 | 84.3 | 1.00 (ref) | |||||
| A | 1000 | 48.4 | 260 | 15.7 | 5.032 (4.296–5.894) | <0.001 | ||||
| Female | rs17276588 genotype | |||||||||
| GG(ref) | 347 | 45.0 | 484 | 76.8 | 1.00 (ref) | |||||
| GA | 366 | 47.5 | 129 | 20.5 | 3.919 (3.061–5.016) | <0.001 | ||||
| AA | 58 | 7.5 | 17 | 2.7 | 3.929 (2.207–6.992) | <0.001 | ||||
| Dominant effect | ||||||||||
| GG (ref) | 347 | 45.0 | 484 | 76.8 | 1.00 (ref) | |||||
| GA+AA | 424 | 55.0 | 146 | 23.2 | 3.920 (3.094–4.966) | <0.001 | ||||
| Recessive effect | ||||||||||
| GA+GG (ref) | 713 | 92.5 | 613 | 97.3 | 1.00 (ref) | |||||
| AA | 58 | 7.5 | 17 | 2.7 | 2.448 (1.385–4.329) | 0.002 | ||||
| rs17276588 allele | ||||||||||
| G (ref) | 1060 | 68.7 | 1097 | 87.1 | 1.00 (ref) | |||||
| A | 482 | 31.3 | 163 | 12.9 | 3.060 (2.514–3.725) | <0.001 | ||||
*
ORs and 95% CIs calculated by logistic regression.
a,b
Adjusted OR(95%CI) and p value, adjusted for age, body mass index, diabetes mellitus, hypertension, history of smoking, history of alcohol use, family history and hyperlipidemia.
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.