. 2023 Apr 18;14(5):591–598. doi: 10.1021/acsmedchemlett.2c00514

Table 2. Biochemical and Cellular SAR of 2-Aminopyrimidine Based EGFR Inhibitors^a.

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EGFR wild-type (WT), L858R (LR), L858R/C797S (LR/CS), and L858R/T790M/C797S (LR/TM/CS) were measured by HTRF-Assay. EGFR wild-type dependent A431 cells and EGFR-L858R/C797S dependent Ba/F3 cells were measured by CTG assay.

Table 2. Biochemical and Cellular SAR of 2-Aminopyrimidine Based EGFR Inhibitorsa.

Table 2. Biochemical and Cellular SAR of 2-Aminopyrimidine Based EGFR Inhibitors^a.