Fig. 4.

Patient Examples with Discrepancy Between Lugano, RECIL and LYRIC. PET/CT images of patient example 1 are illustrated in the upper panel with baseline scan on the left (A) and follow-up staging after 90 days (FU2) on the right (B). The patient had progressive metabolic disease of a mediastinal nodal lymphoma manifestation (red circle) without increase in size. All other TL and NTL showed significant DoR, and no NL appeared. This results in progressive disease according to Lugano criteria, but partial response by Cheson criteria and RECIL, and indeterminate response according to LYRIC. The second patient example is shown in the lower panel (C + D) with a progressive metabolic disease of the spleen without further increase in size. This was defined as PD by Lugano criteria and IR by LYRIC. The decrease in size of all other TLs indicated response according to RECIL (PR) and stable disease according to Cheson criteria