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. 2023 May 12;12(1):2204746. doi: 10.1080/2162402X.2023.2204746

Figure 2.

Figure 2.

Differentially abundant phyla and outcomes. Phylum composition (fraction of total reads) of all patients in the Discovery cohort value is shown in the stacked bar chart (A). After removing phyla with minimal abundance (Clr<-1) and excluding non-Bacteria and non-Archaea taxa, Wilcoxon rank-sum tests were performed to compare their abundance in patients with long- vs short PFS (B). Firmicutes and Actinobacteria are significantly more abundant in patients with short PFS vs long PFS (4.704 vs 3.612 and 6.213 vs 5.935, p = 0.0114 and p = 0.0046, respectively, C and D). Moreover, both Firmicutes/Bacteroidetes (F/B, 1.294 vs 1.132, p = 0.0137, E) and Actinobacteria/Proteobacteria ratio (A/P, 1.068 vs 0.827, p = 0.0113, F) were significantly increased in patients with short PFS. Metric data are shown as mean and corresponding standard deviation (SD). Statistical significance *P < 0.05; **P < 0.01, ***P<.001.