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. 2023 May 15;6:525. doi: 10.1038/s42003-023-04897-w

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© The Author(s) 2023, corrected publication 2023

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Fig. 7 — a Schematic overview of NF-κB and JAK/STAT signaling axes. Node fill color indicates response classification of transcripts: TNFα (green), IFNγ (blue), TNFα + IFNγ (red), common (orange) and no classification (gray). b Pie charts of transcript AUC as part of the total TNFα + IFN response: TNFα (green), IFNγ (blue), [TNFα + IFNγ] - TNFα – IFNγ (red). c Line plots of synergistic transcript levels and SILAC ratios of correlating proteins after TNFα, IFNγ and TNFα + IFNγ stimulation. The sum of separate TNFα and IFNγ regulation is shown in gray. Circles indicate medians of replicates; error bars show standard deviation (n = 3 biological replicates).