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. 2023 May 15;6:525. doi: 10.1038/s42003-023-04897-w

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© The Author(s) 2023, corrected publication 2023

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Fig. 8 — a Schematic overview of secretomics workflow. b Bar plot of number of significantly regulated proteins per stimulus (moderated t-test, BH-adjusted p < 0.01 and log2 fold change > 1). Colors indicate stimulus: TNFα (green), IFNγ (blue), TNFα + IFNγ (red). c Interaction network of differentially regulated proteins after 24 h TNFα + IFNγ stimulation showing protein type per hub indicated in gray. d Heatmap of enriched proteins in the cytokine registry per omics level showing correlating transcripts and proteins in lysate after TNFα, IFNγ and TNFα + IFNγ stimulation. Color gradient indicates z-scores. Several proteins are highlighted in line plots showing VST and LFQ values, error bars show standard deviation (n = 3 biological replicates). e Number of papers enriching for cell type interactions by cytokines induced per stimulation. Node size represents number of papers, per stimulus largest node is set to most cited cell type (TNFα: n citations = 566, IFNγ: n = 140, TNFα + IFNγ: n = 153).