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. 2023 May 15;14:2782. doi: 10.1038/s41467-023-38108-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A (upper left) A DH270 antibody Fab bound HIV-1 Envelope (Env) ectodomain highlighting the gp120 (blue) and gp41 (orange) subunits. Antibody Fab heavy and light chains are colored red and grey, respectively, with epitope glycans depicted in stick representation. (right) Zoomed-in, top and side views of the paratope-epitope contacts. Dashed circles indicate distinct contact regions. (lower left) Number indicators identify contact sites highlighted by the dashed circles in the panels to the right. B The inferred DH270 clone phylogenetic tree depicting cryo-EM maps determined for each clonal member Fab bound to the CH848 d949 trimer (white). The clonal member names are colored according to the Fab color of each map. Black numbering indicates locations of consequential mutations in each antibody according to sites listed in A. Affinities for antibodies on the path leading to the most broad and potent mature form, M6, are indicated in pink. Intermediate clonal members are denoted with an I while mature antibodies are denoted with an M.