TABLE 2.
LCModel Spectral Fit Output of a Single Representative GM and WM Voxel for Selected Metabolites From the First (5 Minutes) and Last (60 Minutes) Time Points After d-Glucose Ingestion
| Metabolite | GM Voxel | WM Voxel | ||
|---|---|---|---|---|
| Concentration, a.u. (CRLB, %) | Concentration, a.u. (CRLB, %) | |||
| 5 Min | 65 Min | 5 Min | 65 Min | |
| tCr | 1.07E4 (4%) | 1.00E4 (5%) | 7.47E3 (5%) | 6.75E3 (4%) |
| tNAA | 2.25E4 (3%) | 2.25E4 (3%) | 1.90E4 (3%) | 2.03E4 (2%) |
| Glx4* | 2.10E4 (7%) | 1.53E4 (10%) | 1.09E4 (10%) | 9.00E3 (11%) |
| Glx23 | 2.68E4 (5%) | 2.76E4 (5%) | 1.36E4 (8%) | 1.44E4 (6%) |
| Glu4* | 1.44E4 (7%) | 1.06E4 (10%) | 7.77E3 (10%) | 6.21E3 (12%) |
| Glu23 | 1.83E4 (7%) | 1.82E4 (8%) | 8.51E3 (11%) | 6.60E3 (16%) |
| Gln4* | 6.55E3 (12%) | 4.63E3 (17%) | 3.11E3 (18%) | 2.80E3 (19%) |
| Gln23 | 8.46E3 (13%) | 9.36E3 (13%) | 5.11E3 (17%) | 7.76E3 (12%) |
| Cr | 7.13E3 (13%) | 5.84E3 (17%) | 5.58E3 (12%) | 4.00E3 (15%) |
| PCr | 3.60E3 (24%) | 4.19E3 (24%) | 1.89E3 (34%) | 2.75E3 (22%) |
| NAA | 2.12E4 (3%) | 2.21E4 (3%) | 1.69E4 (3%) | 1.68E4 (3%) |
| NAAG | 1.30E3 (30%) | 4.15E2(111%) | 2.17E3 (14%) | 3.54E3 (9%) |
Respective spectra and LCModel fits are shown in Figure 3. Data are for unlabeled metabolites unless otherwise indicated.
*Deuterium labeled.
GM indicates gray matter; WM, white matter; a.u., arbitrary units; tCr, total creatine; tNAA, total N-acetylaspartate; Glx, glutamate + glutamine; Glu, glutamate; Gln, glutamine; CRLB, Cramer-Rao lower bound; Cr, creatine; PCr, phosphocreatine; NAA, N-acetylaspartate; NAAG, N-acetylaspartylglutamic acid.