TABLE 3.
Studies' Results
| Author (Year) | Measure | Effect of cSAs on Tumor Uptake | Effect of cSAs on Healthy Organ Uptake | ||||
|---|---|---|---|---|---|---|---|
| Histology | Tumor | Spleen | Liver | Kidneys | Others | ||
| Dörr et al (1993)5 | Semiquantitative | NET | T/L: >20%* | Decrease (60%) | Decrease (28%) | Decrease (17%) | NA |
| Soresi et al (1997)6 | Semiquantitative | SCLC | Increase in ratios T/Lg: 1.98 vs 1.83 T/L: 0.78 vs 0.67 |
NA | NA | NA | NA |
| Janson et al (1999)7 | Semiquantitative | NET | T/B: +50% (−79% to 1085%) | Decrease (55%) | NA | NA | NA |
| Rolleman et al (2007)8 | Semiquantitative | NET | T: NS (−15%) | Decrease (69%) | NS (decrease 17%) | NS (decrease 18%) | NA |
| Velikyan et al (2010)9 | SUV | NET | T/L: increase (1%–223%) | Decrease (>40%*) | Decrease (>20%*) | Decrease (20%*) | NA |
| Haug et al (2011)10 | SUV | NET | T: NS (21.7 vs 20.6) | NS (21.7 vs 23.3) | Decrease (7.1 vs 9.1) | NA | Adrenals: NS (7.8 vs 16.9) |
| Ayati et al (2017)11 | SUV | NET | T: NS | Decrease (18.8 vs 24.5) | Decrease (7.6 vs 9.8) | NA | Adrenals: NS (14.6 vs 14.9) Pituitary: NS (6.2 vs 6.3) Thyroid: decrease (2.6 vs 3.9) |
| Aalbersberg et al (2018)12 |
SUV | NET | T/L: increase (2.59 vs 2.21) | Decrease (22.4 vs 25.8) | Decrease (9.1 vs 10.2) | NS (20.7 vs 19.8) | Adrenals: NS (20.6 vs 19.2) Pituitary: NS (7.1 vs 6.6) Parotid: NS (4.2 vs 4.0) Thyroid: decrease (3.1 vs 4.1) Bone marrow: NS (2.2 vs 2.4) |
| Cherk et al (2018)13 | SUV | NET | T: NS | Decrease (23.1 vs 30.3) | Decrease (8 vs 10.3) | NA | Adrenals: NS Pituitary: increase (11.9 vs 10.2) Thyroid: decrease (3.5 vs 5.9) |
| Gålne et al (2019)14 | SUV | NET | T/L: increase (5.6 vs 2.6) | NA | Decrease (6.0 vs 8.6) | NA | NA |
| Jahn et al (2021)15 | SUV | NET | T: decrease (1 h: 0%–60%*) | Decrease (at 1 h: 60%–80%*) | Decrease (at 1 h: 40%–60%) | NA | Pancreas: decrease (40%–60%*) |
| Lodge et al (2021)3 | SUV | NET | NS (12.8 vs 12.4) | Decrease (4.6 vs 8.8) | Decrease (2.7 vs 3.7) | NS (6.4 vs 6.2) | Red marrow: NS (1.1 vs 1.0) Pituitary: NS (5.9 vs 7.4) |
Effects of cSAs on tumor or healthy organs' uptake are presented either as percentage value (%) or with changes in SUVmax values.
*Estimated based on figures.
B, background; L, liver; Lg, lung; NA, not available; NS, nonsignificant; T, tumor.