Table 5:
The hazard ratios of end-stage renal disease for hospitalization with infection with and without a concurrent diagnosis of acute kidney injury: ARIC 1996-2015
|
|
|||||
|---|---|---|---|---|---|
| Outcomes | Infection-related hospitalization |
||||
| All major infection (2,642 events) |
Pneumonia (1,278 events) |
Urinary tract infection (1,341 events) |
Bloodstream infection (685 events) |
Cellulitis and osteomyelitis (559 events) |
|
| Infection with acute kidney injury | 503 events | 279 events | 289 events | 323 events | 94 events |
| Hazard ratio (95%CI)* | |||||
| Model 1 | 19.29 (13.59-27.37) | 20.96 (13.33-32.94) | 20.23 (13.33-30.72) | 12.15 (7.12-20.74) | 16.88 (7.91-36.04) |
| Model 2 | 6.81 (4.73-9.81) | 8.04 (5.03-12.86) | 6.34 (4.09-9.82) | 6.91 (4.04-11.84) | 7.01 (3.24-15.13) |
| Model 3 | 4.39 (3.06-6.30) | 5.00 (3.14-7.95) | 3.84 (2.48-5.95) | 3.86 (2.25-6.61) | 5.21 (2.41-11.27) |
| Infection without acute kidney injury | 2,139 events | 999 events | 1,052 events | 362 events | 465 events |
| Hazard ratio (95%CI)* | |||||
| Model 1 | 4.74 (3.65-6.15) | 4.06 (2.91-5.66) | 3.97 (2.82-5.59) | 5.35 (3.40-8.41) | 5.27 (3.59-7.74) |
| Model 2 | 3.17 (2.43-4.15) | 2.66 (1.89-3.74) | 2.66 (1.88-3.76) | 3.01 (1.90-4.78) | 3.25 (2.20-4.80) |
| Model 3 | 2.03 (1.54-2.66) | 1.77 (1.26-2.50) | 1.81 (1.28-2.56) | 2.01 (1.26-3.19) | 2.14 (1.44-3.17) |
Model 1 adjusted for age, sex, and race. Model 2 additionally adjusted for body mass index, ever smoking, ever drink, years of education, systolic blood pressure, antihypertensive drugs, diabetes, eGFR (continuous), ACR (continuous), and history of cardiovascular disease, COPD and cancer. Covariates were updated when available. Model 3 additionally adjusted for incident cardiovascular disease. ESRD indicates end-stage renal disease.
*
Reference, person-years in which there was no hospitalization with major infection.