Figure 1.

Schematic representation of transport proteins involved in Bartter’s syndrome. An epithelial cell of the thick ascending limb of the Loop of Henle with Na⁺–K⁺–2Cl⁻ cotransporter and renal outer medullary potassium channel (ROMK) at the apical side. Chloride channel ClC-Ka and ClC-Kb with its Barttin subunit, calcium-sensing receptor (CaSR), and Na⁺–K⁺ ATPase channel at the basolateral side