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B-cell receptor and downstream tyrosine-kinase signaling in B-cell tumor growth. BCAP: B-cell PI3K adaptor protein; BCR: B-cell receptor; BTK: Bruton’s tyrosine kinase; ITAM: immunoreceptor tyrosine-based activation motif; PI3K: PI3 kinase; SYK: tyrosine protein kinase Syk; PIP2: phosphatidylinositol 4,5-biphosphate; PIP3: phosphatidylinositol-3,4,5-triphoshate.
