Table 1.
MR results of the causal effect of MMP-1 on ER-negative BC.
| Exposure | Outcome | No. of SNPs | Method | OR (95% CI) | P value | Heterogeneity | Pleiotropy | |
|---|---|---|---|---|---|---|---|---|
| Cochrane's Q | P | P | ||||||
| MMP1 | ER- Breast cancer (Experimental set) | 15 | MR Egger | 0.94(0.85–1.05) | 0.29 | 14.24 | 0.36 | 0.64 |
| Weighted median | 0.91(0.86–0.97) | < 0.01 | ||||||
| Inverse variance weighted | 0.92(0.88–0.97) | < 0.01 | 14.50 | 0.41 | ||||
| Simple mode | 0.89(0.80–1.00) | 0.07 | ||||||
| Weighted mode | 0.91(0.86–0.97) | 0.01 | ||||||
| MMP1 | ER- Breast cancer (Validation set1) | 15 | MR egger | 0.95(0.83–1.09) | 0.50 | 12.44 | 0.49 | 0.71 |
| Weighted median | 0.90(0.83–0.98) | 0.01 | ||||||
| Inverse variance weighted | 0.93(0.87–0.99) | 0.03 | 12.59 | 0.56 | ||||
| Simple mode | 0.91(0.78–1.06) | 0.25 | ||||||
| Weighted mode | 0.90(0.82–0.98) | 0.03 | ||||||
| MMP1 | ER- Breast cancer (Validation set2) | 15 | MR Egger | 0.97(0.82–1.15) | 0.72 | 13.35 | 0.42 | 0.54 |
| Weighted median | 0.94(0.85–1.04) | 0.21 | ||||||
| Inverse variance weighted | 0.92(0.86–1.00) | 0.05 | 13.77 | 0.47 | ||||
| Simple mode | 0.96(0.79–1.16) | 0.69 | ||||||
| Weighted mode | 0.95(0.85–1.05) | 0.33 | ||||||
| MMP1 | ER- Breast cancer (Validation set3) | 15 | MR Egger | 0.86(0.67–1.11) | 0.27 | 10.32 | 0.67 | 0.72 |
| Weighted median | 0.91(0.79–1.05) | 0.19 | ||||||
| Inverse variance weighted | 0.90(0.80–1.11) | 0.08 | 10.46 | 0.73 | ||||
| Simple mode | 1.03(0.80–1.35) | 0.78 | ||||||
| Weighted mode | 0.92(0.80–1.05) | 0.23 | ||||||
| MMP1 |
ER- Breast cancer (Validation set4) |
15 | MR Egger | 0.94(0.80–1.10) | 0.43 | 18.25 | 0.20 | 0.79 |
| Weighted median | 0.92(0.84–1.02) | 0.12 | ||||||
| Inverse variance weighted | 0.92(0.85–1.00) | 0.05 | 18.34 | 0.24 | ||||
| Simple mode | 0.83(0.67–1.03) | 0.11 | ||||||
| Weighted mode | 0.92(0.83–1.02) | 0.15 | ||||||
BC Breast cancer; CI Confidence interval; ER Estrogen receptor; MMP Matrix metalloproteinases; MR Mendelian randomization; OR Odds ratio; SNP Single nucleotide polymorphisms.