Table 3.
MR results of the causal effect of MMP-7 on ER-negative BC.
| Exposure | Outcome | No. of SNPs | Method | OR (95% CI) | P-value | Heterogeneity | Pleiotropy | |
|---|---|---|---|---|---|---|---|---|
| Cochrane's Q | P | P | ||||||
| MMP7 | ER- Breast cancer (Experimental set) | 9 | MR Egger | 1.02(0.90–1.17) | 0.73 | 12.23 | 0.09 | 0.61 |
| Weighted median | 1.03(0.96–1.12) | 0.38 | ||||||
| Inverse variance weighted | 1.05(0.97–1.14) | 0.24 | 12.73 | 0.12 | ||||
| Simple mode | 1.02(0.85–1.22) | 0.83 | ||||||
| Weighted mode | 1.03(0.96–1.12) | 0.43 | ||||||
| MMP7 | ER- Breast cancer (Validation set1) | 9 | MR Egger | 0.99(0.86–1.14) | 0.89 | 4.99 | 0.66 | 0.79 |
| Weighted median | 1.00(0.90–1.11) | 0.97 | ||||||
| Inverse variance weighted | 0.98(0.89–1.07) | 0.60 | 5.07 | 0.75 | ||||
| Simple mode | 0.94(0.78–1.14) | 0.57 | ||||||
| Weighted mode | 0.99(0.88–1.12) | 0.92 | ||||||
| MMP7 | ER- Breast cancer (Validation set2) | 9 | MR Egger | 1.05(0.85–1.29) | 0.67 | 11.34 | 0.12 | 0.60 |
| Weighted median | 1.06(0.92–1.22) | 0.41 | ||||||
| Inverse variance weighted | 1.10(0.96–1.26) | 0.19 | 11.84 | 0.16 | ||||
| Simple mode | 1.20(0.86–1.68) | 0.32 | ||||||
| Weighted mode | 1.04(0.90–1.21) | 0.57 | ||||||
| MMP7 | ER- Breast cancer (Validation set3) | 9 | MR Egger | 1.08(0.79–1.47) | 0.66 | 10.88 | 0.14 | 0.35 |
| Weighted median | 1.13(0.93–1.39) | 0.23 | ||||||
| Inverse variance weighted | 1.22(0.99–1.50) | 0.06 | 12.47 | 0.13 | ||||
| Simple mode | 1.22(0.84–1.78) | 0.34 | ||||||
| Weighted mode | 1.16(0.95–1.41) | 0.19 | ||||||
| MMP7 | ER- Breast cancer (Validation set4) | 9 | MR Egger | 1.05(0.84–1.32) | 0.66 | 12.65 | 0.08 | 0.76 |
| Weighted median | 1.04(0.90–1.19) | 0.61 | ||||||
| Inverse variance weighted | 1.08(0.94–1.25) | 0.28 | 12.82 | 0.12 | ||||
| Simple mode | 1.04(0.77–1.40) | 0.82 | ||||||
| Weighted mode | 1.03(0.89–1.18) | 0.73 | ||||||
BC breast cancer; CI, confidence interval; ER estrogen receptor; MMP Matrix metalloproteinases; MR Mendelian randomization; OR Odds ratio; SNP Single nucleotide polymorphisms.