Table 4.
MR results of the causal effect of MMP-10 on ER-negative BC.
| Exposure | Outcome | No. of SNPs | Method | OR (95% CI) | P value | Heterogeneity | Pleiotropy | |
|---|---|---|---|---|---|---|---|---|
| Cochrane's Q | P | P | ||||||
| MMP10 | ER- Breast cancer (Experimental set) | 9 | MR Egger | 1.01(0.92–1.10) | 0.89 | 10.65 | 0.16 | 0.97 |
| Weighted median | 1.02(0.96–1.09) | 0.58 | ||||||
| Inverse variance weighted | 1.00(0.95–1.06) | 0.86 | 10.65 | 0.22 | ||||
| Simple mode | 1.03(0.92–1.15) | 0.64 | ||||||
| Weighted mode | 1.02(0.95–1.09) | 0.60 | ||||||
| MMP10 | ER- Breast cancer (Validation set1) | 9 | MR Egger | 1.00(0.90–1.11) | 0.99 | 7.39 | 0.39 | 0.86 |
| Weighted median | 1.00(0.91–1.09) | 0.93 | ||||||
| Inverse variance weighted | 0.99(0.93–1.06) | 0.86 | 7.43 | 0.49 | ||||
| Simple mode | 0.98(0.85–1.12) | 0.74 | ||||||
| Weighted mode | 1.01(0.93–1.10) | 0.79 | ||||||
| MMP10 | ER- Breast cancer (Validation set2) | 9 | MR Egger | 1.01(0.83–1.23) | 0.93 | 17.54 | 0.01 | 0.90 |
| Weighted median | 1.00(0.90–1.12) | 0.96 | ||||||
| Inverse variance weighted | 1.00(0.89–1.13) | 1.00 | 17.59 | 0.03 | ||||
| Simple mode | 1.00(0.81–1.24) | 0.97 | ||||||
| Weighted mode | 1.00(0.89–1.12) | 0.94 | ||||||
| MMP10 | ER- Breast cancer (Validation set3) | 9 | MR Egger | 1.02(0.84–1.24) | 0.86 | 8.50 | 0.29 | 0.68 |
| Weighted median | 1.02(0.87–1.20) | 0.78 | ||||||
| Inverse variance weighted | 1.05(0.93–1.19) | 0.43 | 8.73 | 0.37 | ||||
| Simple mode | 1.19(0.95–1.49) | 0.17 | ||||||
| Weighted mode | 1.06(0.90–1.24) | 0.52 | ||||||
| MMP10 | ER- Breast cancer (Validation set4) | 9 | MR Egger | 1.01(0.83–1.22) | 0.93 | 16.88 | 0.02 | 0.92 |
| Weighted median | 1.01(0.90–1.13) | 0.86 | ||||||
| Inverse variance weighted | 1.00(0.89–1.13) | 0.98 | 16.90 | 0.03 | ||||
| Simple mode | 1.04(0.83–1.29) | 0.74 | ||||||
| Weighted mode | 1.01(0.90–1.14) | 0.84 | ||||||
BC breast cancer; CI, confidence interval; ER estrogen receptor; MMP Matrix metalloproteinases; MR Mendelian randomization; OR Odds ratio; SNP Single nucleotide polymorphisms.