Table 5.
MR results of the causal effect of MMP-12 on ER-negative BC.
| Exposure | Outcome | No. of SNPs | Method | OR (95% CI) | P value | Heterogeneity | Pleiotropy | |
|---|---|---|---|---|---|---|---|---|
| Cochrane's Q | P | P | ||||||
| MMP12 | ER- Breast cancer (Experimental set) | 14 | MR Egger | 0.98(0.88–1.08) | 0.64 | 17.70 | 0.13 | 0.39 |
| Weighted median | 1.01(0.96–1.07) | 0.70 | ||||||
| Inverse variance weighted | 1.02(0.96–1.07) | 0.56 | 18.89 | 0.13 | ||||
| Simple mode | 0.98(0.89–1.09) | 0.77 | ||||||
| Weighted mode | 1.01(0.96–1.06) | 0.78 | ||||||
| MMP12 | ER- Breast cancer (Validation set1) | 14 | MR Egger | 1.05(0.93–1.18) | 0.46 | 11.79 | 0.46 | 0.74 |
| Weighted median | 1.05(0.98–1.14) | 0.18 | ||||||
| Inverse variance weighted | 1.07(1.00–1.13) | 0.04 | 11.91 | 0.53 | ||||
| Simple mode | 1.05(0.92–1.19) | 0.49 | ||||||
| Weighted mode | 1.06(0.98–1.14) | 0.20 | ||||||
| MMP12 | ER- Breast cancer (Validation set2) | 14 | MR Egger | 0.91(0.79–1.06) | 0.25 | 10.41 | 0.58 | 0.31 |
| Weighted median | 0.98(0.90–1.08) | 0.73 | ||||||
| Inverse variance weighted | 0.98(0.91–1.05) | 0.59 | 11.56 | 0.56 | ||||
| Simple mode | 0.88(0.73–1.06) | 0.21 | ||||||
| Weighted mode | 0.98(0.90–1.07) | 0.69 | ||||||
| MMP12 | ER- Breast cancer (Validation set3) | 14 | MR Egger | 0.91(0.73–1.14) | 0.43 | 13.92 | 0.31 | 0.68 |
| Weighted median | 0.93(0.82–1.05) | 0.25 | ||||||
| Inverse variance weighted | 0.95(0.85–1.06) | 0.35 | 14.12 | 0.37 | ||||
| Simple mode | 0.98(0.76–1.25) | 0.86 | ||||||
| Weighted mode | 0.95(0.84–1.08) | 0.45 | ||||||
| MMP12 | ER- Breast cancer (Validation set4) | 14 | MR Egger | 0.90(0.78–1.04) | 0.18 | 11.92 | 0.45 | 0.15 |
| Weighted median | 1.00(0.91–1.08) | 0.86 | ||||||
| Inverse variance weighted | 1.00(0.92–1.07) | 0.86 | 14.26 | 0.36 | ||||
| Simple mode | 1.00(0.81–1.18) | 0.83 | ||||||
| Weighted mode | 1.00(0.90–1.08) | 0.77 | ||||||
BC breast cancer; CI, confidence interval; ER estrogen receptor; MMP Matrix metalloproteinases; MR Mendelian randomization; OR Odds ratio; SNP Single nucleotide polymorphisms.